Essential
With each OS X update, memory demands increase. Just updating Garageband took up 13G of RAM on my MBP with nothing else running. Fans ramp up, and the laptop gets too hot for the lap. Memory Cleaner helps by removing the ever increasing loads of rubbish left behind by OS X and various apps. Free and very handy to have around.
NigTuf about
Memory Diag, v2.3